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Prediagnostic serum 25-hydroxyvitamin D and melanoma risk
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- Previous studies of serum 25-hydroxyvitamin D (25(OH)D) in relation to melanoma have shown conflicting results. We conducted a nested case–control study of 708 cases and 708 controls, using prediagnostically collected serum, to study 25(OH)D and melanoma risk in the population-based Janus Serum Bank Cohort. Stratified Cox regression was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) adjusted for ultraviolet radiation (UVR) indicators and stratified by ambient UVB of residence and body mass index (BMI). Non-linear associations were studied by restricted cubic splines. Missing data were handled with multiple imputation by chained equations. We found an HR of melanoma risk of 1.01 (95% CI: 0.99, 1.04) and an HRimputed of 1.02 (95% CI: 1.00, 1.04) per 5-nmol/L increase. The spline model showed exposure-risk curves with significantly reduced melanoma risk between 60 and 85 nmol/L 25(OH)D (reference 50 nmol/L). Non-significant J-shaped curves were found in sub-analyses of subjects with high ambient UVB of residence and of subjects with BMI 2. Our data did not yield persuasive evidence for an association between 25(OH)D and melanoma risk overall. Serum levels within the medium range might be associated with reduced risk, an association possibly mediated by BMI.
- Subjects :
- Adult
Male
medicine.medical_specialty
Skin Neoplasms
Ultraviolet Rays
Population
lcsh:Medicine
Gastroenterology
Article
Body Mass Index
Young Adult
030207 dermatology & venereal diseases
03 medical and health sciences
Cancer epidemiology
0302 clinical medicine
Risk Factors
Internal medicine
Humans
Medicine
Vitamin D
Serum 25 hydroxyvitamin d
education
lcsh:Science
Melanoma
Aged
education.field_of_study
Multidisciplinary
Norway
business.industry
Proportional hazards model
Hazard ratio
lcsh:R
Middle Aged
medicine.disease
Confidence interval
Case-Control Studies
030220 oncology & carcinogenesis
Cohort
Female
lcsh:Q
business
Body mass index
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....51be0dab22c83066f67416c4a306a5f7
- Full Text :
- https://doi.org/10.1038/s41598-020-77155-2