Life-threatening complications after high-dose methotrexate and the benefits of glucarpidase as salvage therapy: a cohort study of 468 patients

Authors :: Stanislas Faguer
Etienne Chatelut
Delphine Larrieu-Ciron
Caroline Protin
Chloé Medrano
Loic Ysebaert
Françoise Huguet
Christian Recher
Suzanne Tavitian
Muriel Picard
Sophie Perriat
Florent Puisset
Sarah Bertoli
Lucie Oberic
Source :: Leukemia & Lymphoma. 62:846-853
Publication Year :: 2020
Publisher :: Informa UK Limited, 2020.
Abstract: The aims of this study were to characterize the incidence and outcomes of severe toxicities following the administration of high-dose methotrexate (HD-MTX; ≥1 g/m2). Among the 468 patients included...

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