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Acquired hemophilia with thrombosis in a cancer patient: an unusual presentation
- Source :
- Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 29(1)
- Publication Year :
- 2017
-
Abstract
- Acquired hemophilia A (AHA) which presents with spontaneous severe intramuscular, mucosal and/or subcutaneous bleeding is a rare bleeding disorder. Even 50% of AHA patients are defined as idiopathic; 10% of cases are related with malignancy. Here, we present a case of AHA in a 43-year-old lady who was diagnosed with malignancy and venous thromboembolism on vena cava 2 years ago. To the best of our knowledge, this is the first report in literature presented with both acquired hemophilia and thrombosis associated with malignancy. A routine workup for malignancy like solid tumors, lymphoproliferative, or myeloproliferative diseases should be performed and followed up for a long time despite clinical improvement for individuals presented with AHA. Moreover, because of warfarin treatment, the diagnosis may be difficult and delayed. Clinicans should rule out AHA in patients who are on warfarin treatment and have abnormal coagulation tests.
- Subjects :
- Adult
medicine.medical_specialty
030204 cardiovascular system & hematology
Malignancy
Hemophilia A
03 medical and health sciences
0302 clinical medicine
Neoplasms
Coagulation testing
medicine
Humans
In patient
health care economics and organizations
business.industry
On warfarin
Cancer
Thrombosis
Hematology
General Medicine
medicine.disease
Dermatology
Acquired hemophilia
Female
Presentation (obstetrics)
business
030215 immunology
Subjects
Details
- ISSN :
- 14735733
- Volume :
- 29
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis
- Accession number :
- edsair.doi.dedup.....51a55fec3bac23ee21452cd5313f7cbf