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Antioxidant and toxicological effects elicited by alpha-lipoic acid in aquatic organisms
- Source :
- Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 162
- Publication Year :
- 2013
-
Abstract
- Lipoic acid (LA) is a disulfide-containing compound derived from octanoic acid that is synthesized in mitochondria. This molecule acts as a co-factor for mitochondrial enzymes that catalyze oxidative decarboxylation reactions. Several antioxidant properties of LA enable it to be considered as an "ideal antioxidant", having diverse benefits that allow it to deal with environmental or biological stress. Some of the effects induced by LA in aquatic organisms render it suitable for use in aquaculture. However, it is necessary to determine the appropriate dose(s) to be used with different species and even organs to maximize the beneficial antioxidant and detoxifying effects and to minimize the pro-oxidant toxic effects. This review analyzes and compiles existing data from aquatic organisms in which both benefits and drawbacks of LA have been described.
- Subjects :
- Aquatic Organisms
Antioxidant
Thioctic Acid
Physiology
Health, Toxicology and Mutagenesis
Alpha-Lipoic Acid
Biological Stress
medicine.medical_treatment
Cell Biology
General Medicine
Mitochondrion
Biology
Toxicology
Biochemistry
Antioxidants
Aquatic organisms
Lipoic acid
chemistry.chemical_compound
chemistry
Dihydrolipoic acid
Inactivation, Metabolic
medicine
Animals
Oxidative decarboxylation
Subjects
Details
- ISSN :
- 15320456
- Volume :
- 162
- Database :
- OpenAIRE
- Journal :
- Comparative biochemistry and physiology. Toxicologypharmacology : CBP
- Accession number :
- edsair.doi.dedup.....5193647622baf14563b2ed417ebd12cb