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Clinical and Laboratory Characteristics and Outcome of Illness Caused by Tick-Borne Encephalitis Virus without Central Nervous System Involvement
- Source :
- Emerging Infectious Diseases, Vol 28, Iss 2, Pp 291-301 (2022), Emerging Infectious Diseases
- Publication Year :
- 2022
- Publisher :
- Centers for Disease Control and Prevention (CDC), 2022.
-
Abstract
- Illness progressed to encephalitis in 84% of patients within 18 days after defervescence.<br />Information on febrile illness caused by tick-borne encephalitis virus (TBEV) without central nervous system involvement is limited. We characterized 98 patients who had TBEV RNA in their blood but no central nervous system involvement at the time of evaluation. Median duration of illness was 7 days; 37 (38%) patients were hospitalized. The most frequent findings were malaise or fatigue (98%), fever (97%), headache (86%), and myalgias (54%); common laboratory findings were leukopenia (88%), thrombocytopenia (59%), and abnormal liver test results (63%). During the illness, blood leukocyte counts tended to improve, whereas thrombocytopenia and liver enzymes tended to deteriorate. At the time of positive PCR findings, 0/98 patients had serum IgG TBEV and 7 serum IgM TBEV; all patients later seroconverted. Viral RNA load was higher in patients with more severe illness but did not differ substantially in relation to several other factors. Illness progressed to tick-borne encephalitis in 84% of patients within 18 days after defervescence.
- Subjects :
- Microbiology (medical)
tick-borne encephalitis virus
febrile illness
Epidemiology
vector-borne infections
Slovenia
thrombocytopenia
TBE
Infectious and parasitic diseases
RC109-216
Clinical and Laboratory Characteristics and Outcome of Illness Caused by Tick-Borne Encephalitis Virus without Central Nervous System Involvement
Antibodies, Viral
Encephalitis Viruses, Tick-Borne
TBEV
Humans
viruses
leukopenia
tick-borne encephalitis
Viral Load
central nervous system
Infectious Diseases
Synopsis
RNA, Viral
Medicine
meningitis/encephalitis
Encephalitis, Tick-Borne
Illness Caused by TBEV without CNS Involvement
Subjects
Details
- ISSN :
- 10806059 and 10806040
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Emerging Infectious Diseases
- Accession number :
- edsair.doi.dedup.....5185c073b601e5f26d8b43a879d0b530