Enantioselective cyclization of enamide-ynes and application to the synthesis of the kopsifoline core

Authors :: Stephen T. Heller
F. Dean Toste
Yi-Ming Wang
Britton K. Corkey
Source :: Tetrahedron. 69(27-28)
Publication Year :: 2013
Abstract: We report the palladium-catalyzed enantioselective cyclization of 1,6-enamidynes to form spirocyclic ring systems. We applied this methodology to the concise synthesis of the skeletal core of the kopsifoline alkaloids.

Subjects :: Stereochemistry
Chemistry
Organic Chemistry
Drug Discovery
Enantioselective synthesis
Ring (chemistry)
Biochemistry
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