Unusual Case of Adrenocortical Hyperfunction

The case of a young female patient suffering from Cushing's syndrome is described and discussed. Her adrenal pathology was characterized by the existence of multiple small adenomata, probably functional and independent of pituitary control. Clinically, removal of one gland followed by pituitary irradiation resulted in a disappearance of her symptomatology, except for a transient relapse coinciding with a successful pregnancy. One striking biochemical finding was a plasma cortisol binding capacity reduced to half the normal value.