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Regulation of Wnt Signaling by Sox Proteins
- Source :
- Molecular Cell. 4:487-498
- Publication Year :
- 1999
- Publisher :
- Elsevier BV, 1999.
-
Abstract
- Using a functional screen in Xenopus embryos, we identified a novel function for the HMG box protein XSox17β. Ectopic expression of XSox17β ventralizes embryos by inhibiting the Wnt pathway downstream of β-catenin but upstream of the Wnt-responsive gene Siamois . XSox17β also represses transactivation of a TCF/LEF-dependent reporter construct by Wnt and β-catenin. In animal cap experiments, it both activates transcription of endodermal genes and represses β-catenin-stimulated expression of dorsal genes. The inhibition activity of XSox17β maps to a region C-terminal to the HMG box; this region of XSox17β physically interacts with the Armadillo repeats of β-catenin. Two additional Sox proteins, XSox17α and XSox3, likewise bind to β-catenin and inhibit its TCF-mediated signaling activity. These results reveal an unexpected mechanism by which Sox proteins can modulate Wnt signaling pathways.
Details
- ISSN :
- 10972765
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Molecular Cell
- Accession number :
- edsair.doi.dedup.....51693c5f713cd601a71b1de82eb9cc8c