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Prospective study on the association between serum amino acid profiles and depressive symptoms among the Japanese working population
- Source :
- PLoS ONE, PLoS ONE, Vol 16, Iss 8, p e0256337 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- ObjectiveAccumulating evidence suggests that amino acids, particularly tryptophan and glutamate, play an important role in the pathology of depression, but prospective epidemiologic data on this issue is scarce. We examined the association between circulating amino acids and the risk of depressive symptoms in a Japanese working population.MethodsParticipants were 841 workers who were free from depressive symptoms and provided blood at baseline and completed 3-yr follow-up survey. 30 varieties of amino acid concentrations in serum were measured using liquid chromatography/mass spectrometry. Depressive symptoms were defined using the Center for Epidemiologic Studies Depression Scale. Logistic regression was used to calculate the odds ratios of depressive symptoms according to serum amino acids with adjustment for lifestyle factors.ResultsA total of 151 (18.0%) workers were newly identified as having depressive symptoms at the follow-up. Baseline tryptophan and glutamate concentrations in serum were not appreciably associated with the risk of depressive symptoms. Risk of depressive symptoms tended to increase with increasing arginine concentrations; the multivariable-adjusted odds ratio for the highest versus lowest tertile of serum arginine was 1.65 (95% confidence interval: 0.96–2.83; P for trend = 0.07). No clear association was found for other amino acids.ConclusionsResults of the present study do not support a significant role of circulating amino acids in the development of depressive symptoms among Japanese.
- Subjects :
- Male
Arginine
Economics
Epidemiology
Social Sciences
Physiology
Logistic regression
Biochemistry
Mass Spectrometry
Aromatic Amino Acids
Japan
Odds Ratio
Medicine and Health Sciences
Medicine
Public and Occupational Health
Prospective Studies
Amino Acids
Prospective cohort study
Depression (differential diagnoses)
chemistry.chemical_classification
Multidisciplinary
Depression
Organic Compounds
Tryptophan
Neurochemistry
Neurotransmitters
Middle Aged
Center for Epidemiologic Studies Depression Scale
Amino acid
Chemistry
Physical Sciences
Amino Acid Analysis
Female
Glutamate
Basic Amino Acids
Research Article
Adult
Employment
Science
Glutamic Acid
Jobs
Research and Analysis Methods
Mental Health and Psychiatry
Humans
Molecular Biology Techniques
Molecular Biology
Aged
Molecular Biology Assays and Analysis Techniques
Mood Disorders
business.industry
Organic Chemistry
Chemical Compounds
Biology and Life Sciences
Proteins
Physical Activity
Odds ratio
Health Surveys
Confidence interval
Logistic Models
chemistry
Labor Economics
Medical Risk Factors
business
Chromatography, Liquid
Neuroscience
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....516448a550094e794fb56d95908433ef