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Comparison of Plasma Tissue Factor Levels in Unstable and Stable Angina Pectoris
- Source :
- The American Journal of Cardiology. 81:22-26
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- We have reported that the plasma levels of plasma fibrinopeptide A and plasminogen activator inhibitor activity increase in patients with unstable angina and acute myocardial infarction. Tissue factor (TF) is a low-molecular-weight glycoprotein that binds to and acts on essential cofactor VII, and the resulting complex activates factors IX and X, initiating the coagulation cascade. We measured plasma TF antigen levels in 21 patients with unstable angina (on admission and after treatment), 27 patients with stable exertional angina, and 27 control subjects. The 3 groups were matched for age, gender, and other clinical variables. The plasma TF antigen levels were higher in the unstable angina group than in the stable exertional angina and control groups (240 +/- 75 vs 184 +/- 46 and 177 +/- 37 pg/ml, p0.01). There were no significant differences in the plasma TF antigen levels between the stable exertional angina and the control groups. Furthermore, the plasma TF antigen levels were reexamined after treatment in the 21 patients with unstable angina. The mean level in these 21 patients decreased after 2 weeks of treatment (from 240 +/- 75 to 206 +/- 57 pg/ml, p0.01). This study suggests that the plasma TF antigen levels correlate with disease activity in patients with unstable angina. The increased plasma TF antigen levels in patients with unstable angina may reflect intravascular procoagulant activity.
- Subjects :
- Adult
Male
medicine.medical_specialty
Physical Exertion
Coronary Disease
Coronary Angiography
Severity of Illness Index
Stable angina
Angina Pectoris
Thromboplastin
Tissue factor
Antigen
Internal medicine
Blood plasma
medicine
Humans
Angina, Unstable
cardiovascular diseases
Myocardial infarction
Aged
Unstable angina
business.industry
Plasma levels
Middle Aged
medicine.disease
Case-Control Studies
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Plasminogen activator
Subjects
Details
- ISSN :
- 00029149
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- The American Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....514c05db5e39b4862885440188a7fc8b