Back to Search
Start Over
The prognosis of mixed connective tissue disease
- Source :
- Rheumatic diseases clinics of North America. 31(3)
- Publication Year :
- 2005
-
Abstract
- The prognosis for patients who have mixed connective tissue disease (MCTD) varies from a benign course to severe progressive disease. In approximately one third of patients the clinical symptoms go into long-term remission and the anti-U1 small nuclear ribonucleoprotein antibodies disappear. One third of patients have a severe, progressive disease course. Persistent morbidity often is attributable to arthritis, easy fatiguability, and dyspnea on exertion. The most severe clinical manifestation is pulmonary hypertension which contributes to premature death in patients who have MCTD. Pulmonary hypertension is associated with proliferative vascular abnormalities that involve small pulmonary vessels, rather than interstitial lung disease.
- Subjects :
- Lung Diseases
medicine.medical_specialty
Pathology
Gastrointestinal Diseases
Osteoporosis
Arthritis
Gastroenterology
Ribonucleoprotein, U1 Small Nuclear
Mixed connective tissue disease
Rheumatology
Muscular Diseases
Internal medicine
medicine
Humans
Autoantibodies
Mixed Connective Tissue Disease
business.industry
Interstitial lung disease
medicine.disease
Prognosis
Pulmonary hypertension
Cardiovascular Diseases
Fatiguability
Kidney Diseases
Joint Diseases
business
Small nuclear ribonucleoprotein
Progressive disease
Subjects
Details
- ISSN :
- 0889857X
- Volume :
- 31
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Rheumatic diseases clinics of North America
- Accession number :
- edsair.doi.dedup.....5148b9b60a7ce73785ba23775023a643