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Cognitive Domain Dispersion Association with Alzheimer’s Disease Pathology
- Publication Year :
- 2017
-
Abstract
- Within neuropsychology, the term dispersion refers to the degree of variation in performance between different cognitive domains for an individual. Previous studies have demonstrated that cognitively normal individuals with higher dispersion are at an increased risk for progressing to mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Therefore, we determined 1) whether increased dispersion in older adults was associated with amyloid plaques and neurofibrillary tangles (NFTs) and 2) whether increased cognitive dispersion accurately differentiated MCI and AD from non-cognitively impaired (NCI) individuals. The intra-subject standard deviation (ISD) was used to quantify cognitive dispersion, and receiver operator characteristic (ROC) analysis determined whether ISD differentiated MCI and AD from NCI. Neuropathological scores for diffuse plaques (DPs), neuritic plaques (NPs), and NFTs were used as outcome measures in a series of negative binomial regression models. Regression analyses found that increased ISD was associated with increased NFT pathology (β = 10.93, SE = 3.82, p = 0.004), but not with DPs (β = 1.33, SE = 8.85, p = 0.88) or NPs (β = 14.64, SE = 8.45, p = 0.08) after adjusting for age at death, gender, education, APOE e4 status, and clinical diagnosis. An interaction term of ISD with age at death also showed a significant negative association (β = –0.13, SE = 0.04, p = 0.004), revealing an age-dependent association between ISD with NFTs. The ISD failed to show an acceptable level of diagnostic accuracy for MCI (AUC = 0.60). These findings suggest that increased cognitive dispersion is related to NFT pathology where age significantly affects this association.
- Subjects :
- 0301 basic medicine
Male
Pathology
medicine.medical_specialty
Statistics as Topic
Neuropathology
Disease
Neuropsychological Tests
Article
Statistics, Nonparametric
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
medicine
Humans
Statistical dispersion
Cognitive Dysfunction
Senile plaques
Association (psychology)
Aged
Aged, 80 and over
Psychiatric Status Rating Scales
Receiver operating characteristic
business.industry
General Neuroscience
Neuropsychology
Cognition
Neurofibrillary Tangles
General Medicine
Psychiatry and Mental health
Clinical Psychology
030104 developmental biology
Female
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....5139e1074146508b73b077c68bafbc1a