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Interleukin 10 and dendritic cells are the main suppression mediators of regulatory T cells in human neurocysticercosis

Authors :
J. V. Proaño Narváez
Graciela Cárdenas
D. Casanova‐Hernández
Diana Denisse Álvarez-Luquín
Agnès Fleury
Laura Adalid-Peralta
Gladis Fragoso
F. García‐Vázquez
Asiel Arce-Sillas
Marisela Hernández
Edda Sciutto
Source :
Clinical and experimental immunology. 183(2)
Publication Year :
2015

Abstract

Summary Neurocysticercosis is caused by the establishment of Taenia solium cysticerci in the central nervous system. It is considered that, during co-evolution, the parasite developed strategies to modulate the host’s immune response. The action mechanisms of regulatory T cells in controlling the immune response in neurocysticercosis are studied in this work. Higher blood levels of regulatory T cells with CD4+CD45RO+forkhead box protein 3 (FoxP3)high and CD4+CD25highFoxP3+CD95high phenotype and of non-regulatory CD4+CD45RO+FoxP3med T cells were found in neurocysticercosis patients with respect to controls. Interestingly, regulatory T cells express higher levels of cytotoxic T lymphocyte antigen 4 (CTLA-4), lymphocyte-activation gene 3 (LAG-3), programmed death 1 (PD-1) and glucocorticoid-induced tumour necrosis factor receptor (GITR), suggesting a cell-to-cell contact mechanism with dendritic cells. Furthermore, higher IL-10 and regulatory T cell type 1 (Tr1) levels were found in neurocysticercosis patients’ peripheral blood, suggesting that the action mechanism of regulatory T cells involves the release of immunomodulatory cytokines. No evidence was found of the regulatory T cell role in inhibiting the proliferative response. Suppressive regulatory T cells from neurocysticercosis patients correlated negatively with late activated lymphocytes (CD4+CD38+). Our results suggest that, during neurocysticercosis, regulatory T cells could control the immune response, probably by a cell-to-cell contact with dendritic cells and interleukin (IL)-10 release by Tr1, to create an immunomodulatory environment that may favour the development of T. solium cysticerci and their permanence in the central nervous system.

Details

ISSN :
13652249
Volume :
183
Issue :
2
Database :
OpenAIRE
Journal :
Clinical and experimental immunology
Accession number :
edsair.doi.dedup.....513669b38d00ffe56f9b6ab1db584a8c