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Central proliferation and neurogenesis is impaired in type 2 diabetes and prediabetes animal models
- Source :
- PLoS ONE, Vol 9, Iss 2, p e89229 (2014), PLoS ONE, Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- This is an open-access article distributed under the terms of the Creative Commons Attribution License.<br />Type 2 diabetes (T2D) is an important risk factor to suffer dementia, including Alzheimer's disease (AD), and some neuropathological features observed in dementia could be mediated by T2D metabolic alterations. Since brain atrophy and impaired neurogenesis have been observed both T2D and AD we analyzed central nervous system (CNS) morphological alterations in the db/db mice (leptin receptor KO mice), as a model of long-term insulin resistance and T2D, and in C57Bl6 mice fed with high fat diet (HFD), as a model of diet induced insulin resistance and prediabetes. Db/db mice showed an age-dependent cortical and hippocampal atrophy, whereas in HFD mice cortex and hippocampus were preserved. We also detected increased neurogenesis and cell proliferation rates in young db/db mice when compared with control littermates. Our study shows that metabolic parameters serve as predictors of both atrophy and altered proliferation and neurogenesis in the CNS. Moreover in the cortex, atrophy, cell proliferation and neurogenesis were significantly correlated. Our data suggest that T2D may underline some of the pathological features observed in the dementia process. They also support that blood glucose control in elderly patients could help to slow down dementia evolution and maybe, improve its prognosis. © 2014 Ramos-Rodriguez et al.<br />RYC-2008-02333, Junta de Andalucia, Proyectos de Excelencia (P11-CTS-7847), Instituto de Salud Carlos III and FEDER (European Union), cofinanced by Fondo Europeo de Desarrollo Regional ‘‘Una manera de hacer Europa’’ PI12/00675 (Monica Garcia-Alloza) IC-C: RYC-2011-08101, ISCIII Subdirección General de Evaluación y Fomento de la Investigación, Spain (PS09/00671), Europe-FP7 Marie Curie grant (IRG-247835).
- Subjects :
- Blood Glucose
Male
Anatomy and Physiology
medicine.medical_treatment
Mice, Obese
ComputingMilieux_LEGALASPECTSOFCOMPUTING
Type 2 diabetes
Immunoenzyme Techniques
Mice
0302 clinical medicine
Endocrinology
Pathology
Insulin
Prediabetes
Neuropathology
Mice, Knockout
0303 health sciences
Multidisciplinary
Neurogenesis
Brain
3. Good health
Mental Health
Neurology
Receptors, Leptin
Medicine
Research Article
medicine.medical_specialty
Science
Biology
Diet, High-Fat
Prediabetic State
03 medical and health sciences
Atrophy
Insulin resistance
Diagnostic Medicine
Alzheimer Disease
Diabetes mellitus
Internal medicine
medicine
Animals
030304 developmental biology
Cell Proliferation
Diabetic Endocrinology
Leptin receptor
Diabetes Mellitus Type 2
medicine.disease
Disease Models, Animal
Diabetes Mellitus, Type 2
Anatomical Pathology
Metabolic Disorders
Dementia
Insulin Resistance
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....511e827a62a8b08047e67415e9e91ffd