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Prognostic nomogram of xerostomia for patients with nasopharyngeal carcinoma after intensity-modulated radiotherapy
- Source :
- Aging (Albany NY)
- Publication Year :
- 2019
-
Abstract
- Xerostomia is a common radiation-induced late complication after radiotherapy. Identifying predictive factors for xerostomia will lead to better treatments and improve the quality of life. This study was conducted to establish an effective predictive nomogram for xerostomia by assessing stage I-IVb (AJCC 7th edition) NPC patients between September 2015 and March 2016. Xerostomia was evaluated via the RTOG/EORTC system. The primary endpoint was grade 2-3 xerostomia 1 year after treatment. The predictive factors for xerostomia were analysed using logistic regression analysis. A nomogram was constructed based on combining the predictors and clinical variables. In total, 102 patients with grade 0-1 xerostomia and 93 patients with grade 2-3 xerostomia were included. The independent predictive factors for xerostomia were V25, V30, V35, and V45 of the ipsilateral parotid gland and mean dose of the contralateral parotid gland. The calibration plot for the probability of xerostomia showed good agreement between prediction by the nomogram and actual observation. The concordance index of the nomogram for predicting xerostomia was 0.796 (95% CI: 0.735-0.857, P
- Subjects :
- Adult
Male
Aging
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Logistic regression
Xerostomia
Young Adult
stomatognathic system
medicine
Clinical endpoint
otorhinolaryngologic diseases
Humans
Stage (cooking)
Neoplasm Staging
Retrospective Studies
Nasopharyngeal Carcinoma
business.industry
Nasopharyngeal Neoplasms
Cell Biology
Nomogram
Middle Aged
medicine.disease
Prognosis
intensity-modulated radiotherapy
Parotid gland
Radiation therapy
stomatognathic diseases
Nomograms
medicine.anatomical_structure
Nasopharyngeal carcinoma
ROC Curve
Female
Intensity modulated radiotherapy
Radiology
Radiotherapy, Intensity-Modulated
Neoplasm Grading
business
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 12
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....51138d43cb21e3571286391ddf4f631a