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Association of three polymorphisms in ARID5B, IKZF1 and CEBPE with the risk of childhood acute lymphoblastic leukemia in a Chinese population
- Source :
- Gene. 524(2)
- Publication Year :
- 2012
-
Abstract
- Recent genome-wide association studies (GWAS) that focus on childhood acute lymphoblastic leukemia (ALL), the most common malignancy in children younger than 15 years old, have found evidence that single nucleotide polymorphisms (SNPs) in IKZF1 (7p12.2), ARID5B (10q21.2) and CEBPE (14q11.2) are strongly related to the risk of childhood ALL. These polymorphisms may lead to abnormal expression and dysfunction of the corresponding transcription factors and are likely to increase the risk of ALL. To validate the relationship between these SNPs and the risk of childhood ALL in Chinese population, we conducted a case-control study of 570 ALL cases and 673 controls. We determined that the SNP rs10821936 in ARID5B was statistically significantly associated with the risk of childhood ALL (P0.0001). The results were also significant for the subgroup analysis of high-risk, medium-risk and low-risk ALL as well as B-lineage ALL. Statistically significant differences were not found in the SNPs for IKZF1 and CEBPE. In conclusion, ARID5B rs10821936 could serve as a potential biomarker for assessing the risk of childhood ALL in Chinese children.
- Subjects :
- Oncology
Male
medicine.medical_specialty
China
Heterozygote
Adolescent
Genotyping Techniques
Single-nucleotide polymorphism
Genome-wide association study
Biology
Malignancy
Polymorphism, Single Nucleotide
Ikaros Transcription Factor
Asian People
Risk Factors
Internal medicine
Genetics
medicine
SNP
Humans
Genetic Predisposition to Disease
Child
Childhood Acute Lymphoblastic Leukemia
Alleles
Genetic Association Studies
Genetic association
Chinese population
Infant
General Medicine
CEBPE
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
DNA-Binding Proteins
Case-Control Studies
Child, Preschool
CCAAT-Enhancer-Binding Proteins
Female
Biomarkers
Transcription Factors
Subjects
Details
- ISSN :
- 18790038
- Volume :
- 524
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Gene
- Accession number :
- edsair.doi.dedup.....511238a5623affa4e6453fc1cecc3f46