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Mechanisms and biomarkers of liver regeneration after drug-induced liver injury
- Source :
- Adv Pharmacol
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Liver, the major metabolic organ in the body, is known for its remarkable capacity to regenerate. Whereas partial hepatectomy (PHx) is a popular model for the study of liver regeneration, the liver also regenerates after acute injury, but less is known about the mechanisms that drive it. Recent studies have shown that liver regeneration is critical for survival in acute liver failure (ALF), which is usually due to drug-induced liver injury (DILI). It is sometimes assumed that the signaling pathways involved are similar to those that regulate regeneration after PHx, but there are likely to be critical differences. A better understanding of regeneration mechanisms after DILI and hepatotoxicity in general could lead to development of new therapies for ALF patients and new biomarkers to predict patient outcome. Here, we summarize what is known about the mechanisms of liver regeneration and repair after hepatotoxicity. We also review the literature in the emerging field of liver regeneration biomarkers.
- Subjects :
- Drug
media_common.quotation_subject
Partial hepatectomy
Bioinformatics
medicine.disease_cause
Article
Ischemic hepatitis
medicine
Animals
Hepatectomy
Humans
media_common
Liver injury
business.industry
Regeneration (biology)
digestive, oral, and skin physiology
medicine.disease
Liver regeneration
Liver Regeneration
Acetaminophen
Liver
Acute injury
Chemical and Drug Induced Liver Injury
business
Biomarkers
Signal Transduction
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Adv Pharmacol
- Accession number :
- edsair.doi.dedup.....50e03b20ee952a716ce2897b70a8875c