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Cyanidin-3-glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function
- Source :
- Molecular nutritionfood research. 61(11)
- Publication Year :
- 2017
-
Abstract
- cope Obesity develops when energy intake exceeds energy expenditure. Promoting brown adipose tissue (BAT) formation and function increases energy expenditure and may protect against obesity. Cyanidin-3-glucoside (C3G) is an anthocyanin compound which occurs naturally in many fruits and vegetables. In this study, we investigated the effect and mechanism of C3G on the prevention of obesity. Methods and results Db/db mice received C3G dissolved in drinking water for 16 weeks; Drinking water served as the vehicle treatment. The total body weight, energy intake, metabolic rate and physical activity were measured. The lipid droplets, gene expression and protein expression were evaluated by histochemical staining, real-time PCR and western blots. We found that C3G increased energy expenditure, limited weight gain, maintained glucose homeostasis, reversed hepatic steatosis, improved cold tolerance, and enhanced BAT activity in obese db/db mice. C3G also induces brown-like adipocytes (beige) formation in subcutaneous white adipose tissue (sWAT) of db/db mice model. We also found that C3G potently regulates the transcription of UCP1 both in BAT and sWAT through increasing mitochondrial number and function. Conclusion Our results suggest that C3G plays a role in regulating systemic energy balance, which may have potential therapeutic implications for the prevention and control of obesity. This article is protected by copyright. All rights reserved
- Subjects :
- 0301 basic medicine
Male
Thermotolerance
medicine.medical_specialty
Adipose Tissue, White
White adipose tissue
Biology
Anthocyanins
03 medical and health sciences
Adipose Tissue, Brown
Glucosides
Microscopy, Electron, Transmission
Non-alcoholic Fatty Liver Disease
Internal medicine
Lipid droplet
Brown adipose tissue
Gene expression
medicine
Glucose homeostasis
Animals
Whole Body Imaging
Obesity
Uncoupling Protein 1
030109 nutrition & dietetics
Adipogenesis
Behavior, Animal
medicine.disease
Mice, Mutant Strains
Mitochondria
Up-Regulation
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Gene Expression Regulation
Liver
Dietary Supplements
medicine.symptom
Steatosis
Energy Intake
Energy Metabolism
Weight gain
Locomotion
Food Science
Biotechnology
Subjects
Details
- ISSN :
- 16134133
- Volume :
- 61
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Molecular nutritionfood research
- Accession number :
- edsair.doi.dedup.....50d725d9ac185be0886ab922356aec38