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Incorporation of Isotopically Labeled Cocaine into Human Hair: Race as a Factor
- Source :
- Journal of Analytical Toxicology. 22:156-165
- Publication Year :
- 1998
- Publisher :
- Oxford University Press (OUP), 1998.
-
Abstract
- In order to evaluate race as a possible factor affecting the incorporation of drugs into human hair, 2 mg/kg deuterium-labeled cocaine (cocaine-d5) was administered intranasally to nine male non-Caucasian volunteers under controlled laboratory conditions. Sequential blood samples were collected for up to three days, and scalp hair samples were collected at 24 and 72 h after dosing and at monthly intervals for up to 12 months. The samples were then analyzed by gas chromatography-mass spectrometry for cocaine-d5 and benzoylegonine-d5 (BZE-d5). The amounts of cocaine-d5 found in the hair of these non-Caucasian subjects were compared with the amounts of cocaine-d5 found in the hair of Caucasian subjects who received the same cocaine dose under identical conditions as part of a study we reported previously. The non-Caucasians in the present study had approximately 2.7 times more cocaine-d5 in their hair than the Caucasian subjects in the earlier study. In five of the non-Caucasian subjects, cocaine-d5 could be detected in hair within 24 h after dosing. Curiously, we were unable to detect any cocaine-d5 in one of the non-Caucasian subject's hair at any time after dosing even though cocaine-d5 was in plasma at the expected levels. The results from these studies suggest there may be a racial bias in the incorporation of cocaine into human hair; however, the data are not conclusive because of the relatively small sample size.
- Subjects :
- Adult
Male
Substance-Related Disorders
Stereochemistry
Health, Toxicology and Mutagenesis
Black People
Physiology
Toxicology
Gas Chromatography-Mass Spectrometry
White People
Analytical Chemistry
Cocaine
Pharmacokinetics
medicine
Humans
Environmental Chemistry
Dosing
Administration, Intranasal
Chemical Health and Safety
integumentary system
biology
Chemistry
Small sample
Deuterium
biology.organism_classification
Biological materials
Substance Abuse Detection
medicine.anatomical_structure
Isotope Labeling
Scalp
Racial bias
Cabello
Hair
Subjects
Details
- ISSN :
- 19452403 and 01464760
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of Analytical Toxicology
- Accession number :
- edsair.doi.dedup.....50d43c11f200e0e81f8321db6f987d29