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Minor Oral Lesions Facilitate Transmission of Chronic Wasting Diseaseâ–¿
- Publication Year :
- 2010
- Publisher :
- American Society for Microbiology (ASM), 2010.
-
Abstract
- While chronic wasting disease (CWD) prion transmission, entry, and trafficking remain incompletely elucidated, natural exposure of the oral and/or nasal mucous membranes seems certain. Cervids commonly sustain minor lesions on oral mucous membranes that could have an impact on susceptibility to prion infection. To explore this potential cofactor, we studied cohorts of cervid PrP transgenic mice with or without superficial abrasions on the lingual mucosa to determine whether minor oral mucosa lesions may enhance susceptibility to CWD infections. Results demonstrated that minor lingual abrasions substantially facilitate CWD transmission, revealing a cofactor that may be significant in cervids and perhaps other species.
- Subjects :
- Genetically modified mouse
Prions
animal diseases
Immunology
Mice, Transgenic
Biology
Microbiology
law.invention
Lesion
Mice
Prion infection
Tongue
law
Virology
medicine
Animals
Oral mucosa
Lingual mucosa
Mouth Mucosa
Chronic wasting disease
medicine.disease
stomatognathic diseases
Disease Models, Animal
medicine.anatomical_structure
Transmission (mechanics)
Insect Science
Pathogenesis and Immunity
Wasting Disease, Chronic
medicine.symptom
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....50d2ba24caaa3c942edb3f207c0c9764