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Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
- Source :
- International Journal of Nanomedicine
- Publication Year :
- 2018
- Publisher :
- Dove Press, 2018.
-
Abstract
- Qiangying Yi,1 Jin Ma,1 Ke Kang,1 Zhongwei Gu1,2 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 2College of Materials Science and Engineering, Nanjing Tech University, Nanjing, P.R. China Introduction: Increasing demands in precise control over delivery and functionalization of therapeutic agents for tumor-specific chemotherapy have led to a rapid development in nanocarriers. Herein, we report a nanocapsule (NC) system for tumor-oriented drug delivery and effective tumor therapy.Materials and methods: Functionalized hyaluronan is utilized to build up the NC shells, in which bioreduction cleavable sites, targeting ligand folic acid (FA), and zwitterionic tentacles are integrated.Results: The hollow NCs obtained (~50 nm in diameter) showed well-defined spherical shell structures with a shell thickness of ~8 nm. These specially designed NCs (doxorubicin [DOX]/FA-Z-NCs) with high drug encapsulation content exhibited good biocompatibility in vitro and fast intracellular drug release behavior mediated by intracellular glutathione.Conclusion: Cellular uptake tests demonstrated rapid uptake of these functionalized NCs and effective escape from endosomes. Antitumor efficacy of the DOX/FA-Z-NCs was confirmed by the significant tumor growth inhibition effect as well as greatly reduced side effects, in contrast with those of the free drug DOX hydrochloride. Keywords: drug delivery, active targeting, zwitterionic poly(carboxybetaine methacrylate), doxorubicin
- Subjects :
- active targeting
Biocompatibility
Hydrochloride
Biophysics
Pharmaceutical Science
Antineoplastic Agents
Bioengineering
02 engineering and technology
zwitterionic poly(carboxybetaine methacrylate)
010402 general chemistry
doxorubicin
01 natural sciences
Nanocapsules
Biomaterials
chemistry.chemical_compound
Drug Delivery Systems
Folic Acid
International Journal of Nanomedicine
Drug Discovery
Hyaluronic acid
medicine
Animals
Humans
Doxorubicin
Hyaluronic Acid
Original Research
Drug Carriers
Mice, Inbred BALB C
Organic Chemistry
General Medicine
021001 nanoscience & nanotechnology
Xenograft Model Antitumor Assays
0104 chemical sciences
Drug Liberation
chemistry
drug delivery
Drug delivery
Female
Nanocarriers
0210 nano-technology
Drug carrier
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 11782013
- Database :
- OpenAIRE
- Journal :
- International Journal of Nanomedicine
- Accession number :
- edsair.doi.dedup.....50c30707955107c4b6785283fb07b900