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Blocking or enhancing effects of some basic emollients in UVA penetration
- Source :
- Anais Brasileiros de Dermatologia, Anais Brasileiros de Dermatologia v.93 n.2 2018, Anais brasileiros de dermatologia, Sociedade Brasileira de Dermatologia (SBD), instacron:SBD, Anais Brasileiros de Dermatologia, Vol 93, Iss 2, Pp 238-241 (2018), Anais Brasileiros de Dermatologia, Volume: 93, Issue: 2, Pages: 238-241, Published: MAR 2018
- Publication Year :
- 2018
- Publisher :
- FapUNIFESP (SciELO), 2018.
-
Abstract
- Background: Topical agents used in combination with phototherapy or photochemotherapy may have both blocking or enhancing effects in ultraviolet rays. Objective: In this in vivo study, the effects of topical petrolatum, basis cream, glycerine, and olive oil on the transmission of ultraviolet A radiation were investigated. Methods: A test was performed to determine the minimal phototoxic dose on 29 volunteers with only psoralen plus ultraviolet A (PUVA) and then the same test was repeated with white petrolatum, basis cream, glycerine, olive oil, and sunscreen (0.3cc/25cm2). The effects of each agent on the minimal phototoxic dose were determined after 72 h. Results: When compared to pure PUVA, there was a statistically significant increase in the mean minimal phototoxic dose values by the application of white petrolatum (P = 0.011), but there was no significant increase or decrease in the mean minimal phototoxic dose values after the application of basis cream (P = 0.326), glycerine (P = 0.611) or olive oil (P = 0.799). Study limitations: Low number of patients Conclusion: The application of white petrolatum, which has a blocking effect, and also of basis cream immediately before PUVA therapy should not be recommended. Although we specify that glycerine and maybe olive oil can be used before photochemotherapy, there is a need for further research in larger series.
- Subjects :
- Glycerol
medicine.medical_specialty
Time Factors
Petrolatum
Ultraviolet Rays
PUVA therapy
medicine.medical_treatment
Dermatology
Skin Diseases
Ultraviolet A Radiation
Statistics, Nonparametric
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
In vivo
medicine
Humans
Single-Blind Method
Olive Oil
White petrolatum
Psoralen
Skin Tests
Investigation
Photosensitizing Agents
Emollients
business.industry
Reproducibility of Results
Dose-Response Relationship, Radiation
General Medicine
Ultraviolet a
Penetration (firestop)
medicine.drug_formulation_ingredient
Treatment Outcome
Photochemotherapy
chemistry
RL1-803
Ultraviolet rays
030220 oncology & carcinogenesis
Skin Cream
Skin cream
business
Sunscreening Agents
Dermatitis, Phototoxic
Subjects
Details
- ISSN :
- 18064841 and 03650596
- Volume :
- 93
- Database :
- OpenAIRE
- Journal :
- Anais Brasileiros de Dermatologia
- Accession number :
- edsair.doi.dedup.....50bf74e58ca6656fa68d1738197dc69f