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Liver Pathology and SARS-CoV-2 Detection in Formalin-Fixed Tissue of Patients With COVID-19
- Source :
- American Journal of Clinical Pathology
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Objectives The novel coronavirus, severe acute respiratory syndrome coronavirus 2, causing coronavirus disease 2019 (COVID-19) remains a global health threat and a significant source of human morbidity and mortality. While the virus primarily induces lung injury, it also has been reported to cause hepatic sequelae. Methods We aimed to detect the virus in formalin-fixed tissue blocks and document the liver injury patterns in patients with COVID-19 compared with a control group. Results We were able to detect viral RNA in the bronchioalveolar cell blocks (12/12, 100%) and formalin-fixed, paraffin-embedded tissue of the lung (8/8, 100%) and liver (4/9, 44%) of patients with COVID-19. Although the peak values of the main liver enzymes and bilirubin were higher in the patients with COVID-19 compared with the control group, the differences were not significant. The main histologic findings were minimal to focal mild portal tract chronic inflammation (7/8, 88%, P < .05) and mild focal lobular activity (6/8, 75%, P = .06). Conclusions We found that most patients who died of COVID-19 had evidence of mild focal hepatitis clinically and histologically; however, the virus was detected in less than half of the cases.
- Subjects :
- Adult
Male
0301 basic medicine
Gastrointestinal
medicine.medical_specialty
Tissue Fixation
Autopsy
Lung injury
medicine.disease_cause
Gastroenterology
Virus
Cytopathology
03 medical and health sciences
0302 clinical medicine
Hepatopathology
Formaldehyde
Internal medicine
Molecular diagnostics
medicine
Humans
Lung
Aged
Coronavirus
Aged, 80 and over
Inflammation
Liver injury
Hepatitis
SARS-CoV-2
business.industry
COVID-19
General Medicine
Middle Aged
medicine.disease
Human morbidity
030104 developmental biology
medicine.anatomical_structure
Liver
030220 oncology & carcinogenesis
RNA, Viral
Original Article
Female
business
AcademicSubjects/MED00690
Subjects
Details
- ISSN :
- 19437722 and 00029173
- Volume :
- 155
- Database :
- OpenAIRE
- Journal :
- American Journal of Clinical Pathology
- Accession number :
- edsair.doi.dedup.....50b9c37050f5940abdb0682e9755022b