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Biological and Medical Importance of Cellular Heterogeneity Deciphered by Single-Cell RNA Sequencing
- Source :
- Cells, Cells, Vol 9, Iss 1751, p 1751 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- The present review discusses recent progress in single-cell RNA sequencing (scRNA-seq), which can describe cellular heterogeneity in various organs, bodily fluids, and pathologies (e.g., cancer and Alzheimer’s disease). We outline scRNA-seq techniques that are suitable for investigating cellular heterogeneity that is present in cell populations with very high resolution of the transcriptomic landscape. We summarize scRNA-seq findings and applications of this technology to identify cell types, activity, and other features that are important for the function of different bodily organs. We discuss future directions for scRNA-seq techniques that can link gene expression, protein expression, cellular function, and their roles in pathology. We speculate on how the field could develop beyond its present limitations (e.g., performing scRNA-seq in situ and in vivo). Finally, we discuss the integration of machine learning and artificial intelligence with cutting-edge scRNA-seq technology, which could provide a strong basis for designing precision medicine and targeted therapy in the future.
- Subjects :
- Cell type
cell-to-cell heterogeneity
medicine.medical_treatment
genetic processes
Review
Disease
Computational biology
Biology
Targeted therapy
Machine Learning
Transcriptome
Genetic Heterogeneity
transcriptomics
Neoplasms
scRNA-seq
Gene expression
medicine
Animals
Humans
natural sciences
RNA-Seq
lcsh:QH301-705.5
Gene Expression Profiling
Computational Biology
RNA
General Medicine
artificial intelligence
Precision medicine
lcsh:Biology (General)
Cardiovascular Diseases
Single-Cell Analysis
Function (biology)
Subjects
Details
- ISSN :
- 20734409
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....50b839a72072bd9f54f67d393b350ba4