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lncRNA NORAD is consistently detected in breastmilk exosomes and its expression is downregulated in mothers of preterm infants

Authors :
Amalia Sertedaki
Niki Mourtzi
Anastasia Kapetanaki
Eirini Karamichali
Antonis Giannakakis
Margaritis Tsifintaris
Margarita Pesmatzoglou
George Liosis
Androniki Tasiopoulou
Tania Siahanidou
George P. Chrousos
George E. Baltatzis
Dimitrios Vlachakis
Source :
International Journal of Molecular Medicine
Publication Year :
2021
Publisher :
D.A. Spandidos, 2021.

Abstract

Breast milk is the ideal food for infants and undoubtedly has immediate and long‑term benefits. Breast milk contains extracellular vesicles (EVs) i.e., exosomes secreted by maternal breast cells. Exosomes carry genetic material, such as long non‑coding RNAs (lncRNAs), which possibly participate in cell‑to‑cell communications, as they are known to regulate critical gene pathways. The aim of the present study was to screen human breastmilk exosomes for their lncRNA cargo and to examine exosomal lncRNA levels associated with milk obtained from mothers that gave birth at term or prematurely (

Details

Language :
English
ISSN :
1791244X and 11073756
Volume :
48
Issue :
6
Database :
OpenAIRE
Journal :
International Journal of Molecular Medicine
Accession number :
edsair.doi.dedup.....50b82d1703d85ef0350670e716daaef0