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Outcomes of Induction Chemotherapy Plus Intensity-Modulated Radiotherapy (IMRT) Versus IMRT Plus Concurrent Chemotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma: A Propensity Matched Study
- Source :
- Translational Oncology, Translational Oncology, Vol 9, Iss 4, Pp 329-335 (2016)
- Publication Year :
- 2016
-
Abstract
- PURPOSE: It deserves investigation whether induction chemotherapy (IC) followed by intensity-modulated radiotherapy (IMRT) is inferior to the current standard of IMRT plus concurrent chemotherapy (CC) in locoregionally advanced nasopharyngeal carcinoma. METHODS: Patients who received IC (94 patients) or CC (302 patients) plus IMRT at our center between March 2003 and November 2012 were retrospectively analyzed. Propensity-score matching method was used to match patients in both arms at equal ratio. Failure-free survival (FFS), overall survival (OS), distant metastasis–free survival (DMFS), and locoregional relapse–free survival (LRFS) were assessed with Kaplan-Meier method, log-rank test, and Cox regression. RESULTS: In the original cohort of 396 patients, IC plus IMRT resulted in similar FFS (P = .565), OS (P = .334), DMFS (P = .854), and LRFS (P = .999) to IMRT plus CC. In the propensity-matched cohort of 188 patients, no significant survival differences were observed between the two treatment approaches (3-year FFS 80.3% vs 81.0%, P = .590; OS 93.4% vs 92.1%, P = .808; DMFS 85.9% vs 87.7%, P = .275; and LRFS 93.1% vs 92.0%, P = .763). Adjusting for the known prognostic factors in multivariate analysis, IC plus IMRT did not cause higher risk of treatment failure, death, distant metastasis, or locoregional relapse. CONCLUSIONS: IC plus IMRT appeared to achieve comparable survival to IMRT plus CC in locoregionally advanced nasopharyngeal carcinoma. Further investigations were warranted.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Cancer Research
Original article
medicine.medical_treatment
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Concurrent chemotherapy
Internal medicine
medicine
Overall survival
Proportional hazards model
business.industry
Induction chemotherapy
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Radiation therapy
030104 developmental biology
Nasopharyngeal carcinoma
030220 oncology & carcinogenesis
Cohort
Intensity modulated radiotherapy
business
Subjects
Details
- ISSN :
- 19365233
- Volume :
- 9
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Translational oncology
- Accession number :
- edsair.doi.dedup.....50b01ab59def28b1ccffd18d97776026