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Particle therapy for prostate cancer: The past, present and future
- Source :
- International Journal of Urology
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Although prostate cancer control using radiotherapy is dose‐dependent, dose–volume effects on late toxicities in organs at risk, such as the rectum and bladder, have been observed. Both protons and carbon ions offer advantageous physical properties for radiotherapy, and create favorable dose distributions using fewer portals compared with photon‐based radiotherapy. Thus, particle beam therapy using protons and carbon ions theoretically seems suitable for dose escalation and reduced risk of toxicity. However, it is difficult to evaluate the superiority of particle beam radiotherapy over photon beam radiotherapy for prostate cancer, as no clinical trials have directly compared the outcomes between the two types of therapy due to the limited number of facilities using particle beam therapy. The Japanese Society for Radiation Oncology organized a joint effort among research groups to establish standardized treatment policies and indications for particle beam therapy according to disease, and multicenter prospective studies have been planned for several common cancers. Clinical trials of proton beam therapy for intermediate‐risk prostate cancer and carbon‐ion therapy for high‐risk prostate cancer have already begun. As particle beam therapy for prostate cancer is covered by the Japanese national health insurance system as of April 2018, and the number of facilities practicing particle beam therapy has increased recently, the number of prostate cancer patients treated with particle beam therapy in Japan is expected to increase drastically. Here, we review the results from studies of particle beam therapy for prostate cancer and discuss future developments in this field.
- Subjects :
- Male
medicine.medical_specialty
Urology
medicine.medical_treatment
030232 urology & nephrology
Rectum
Review Article
biochemical relapse‐free survival
Disease-Free Survival
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Proton Therapy
Humans
Medicine
carbon‐ion radiotherapy
Prospective cohort study
Particle beam
Review Articles
Randomized Controlled Trials as Topic
Particle therapy
business.industry
Prostate
Prostatic Neoplasms
toxicity
prostate cancer
medicine.disease
proton beam therapy
Clinical trial
Radiation therapy
medicine.anatomical_structure
030220 oncology & carcinogenesis
Practice Guidelines as Topic
Carbon Ion Radiotherapy
Radiology
business
Subjects
Details
- ISSN :
- 14422042 and 09198172
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- International Journal of Urology
- Accession number :
- edsair.doi.dedup.....50a581e58d24643f6a53480270d01ed0