Back to Search
Start Over
Plasticity of Binocularity and Visual Acuity Are Differentially Limited by Nogo Receptor
- Source :
- The Journal of Neuroscience. 34:11631-11640
- Publication Year :
- 2014
- Publisher :
- Society for Neuroscience, 2014.
-
Abstract
- The closure of developmental critical periods consolidates neural circuitry but also limits recovery from early abnormal sensory experience. Degrading vision by one eye throughout a critical period both perturbs ocular dominance (OD) in primary visual cortex and impairs visual acuity permanently. Yet understanding how binocularity and visual acuity interrelate has proven elusive. Here we demonstrate the plasticity of binocularity and acuity are separable and differentially regulated by the neuronal nogo receptor 1 (NgR1). Mice lacking NgR1 display developmental OD plasticity as adults and their visual acuity spontaneously improves after prolonged monocular deprivation. Restricting deletion of NgR1 to either cortical interneurons or a subclass of parvalbumin (PV)-positive interneurons alters intralaminar synaptic connectivity in visual cortex and prevents closure of the critical period for OD plasticity. However, loss of NgR1 in PV neurons does not rescue deficits in acuity induced by chronic visual deprivation. Thus, NgR1 functions with PV interneurons to limit plasticity of binocularity, but its expression is required more extensively within brain circuitry to limit improvement of visual acuity following chronic deprivation.
- Subjects :
- Patch-Clamp Techniques
Visual acuity
genetic structures
Neurogenesis
Visual Acuity
Receptors, Cell Surface
Sensory system
Biology
GPI-Linked Proteins
Ocular dominance
Mice
Interneurons
Nogo Receptor 1
Neuroplasticity
medicine
Animals
Mice, Knockout
Vision, Binocular
Microscopy, Confocal
Neuronal Plasticity
General Neuroscience
Articles
Immunohistochemistry
eye diseases
Mice, Inbred C57BL
Monocular deprivation
Parvalbumins
Visual cortex
medicine.anatomical_structure
biology.protein
medicine.symptom
Neuroscience
Myelin Proteins
Parvalbumin
Subjects
Details
- ISSN :
- 15292401 and 02706474
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- The Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....509132ca6fd3d3108cba4f89e3715452