MiR-200c inhibits bladder cancer progression by targeting lactate dehydrogenase A

// Daozhang Yuan 1 , Shunsheng Zheng 1 , Liyan Wang 1 , Jing Li 1 , Jianan Yang 1 , Bin Wang 1 , Xiong Chen 2 and Xiaobo Zhang 2 1 Department of Urology, Cancer Center of Guangzhou Medical University, Guangzhou, People’s Republic of China 2 Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, People’s Republic of China Correspondence to: Daozhang Yuan, email: daozhangyuan@163.com Xiaobo Zhang, email: zhangxiaobo3537@163.com Keywords: microRNA, miR-200c, LDHA, bladder cancer, proliferation Received: November 09, 2016 Accepted: June 02, 2017 Published: June 28, 2017 ABSTRACT Lactate dehydrogenase A (LDHA) is overexpressed in various cancers. We investigated LDHA expression and function in bladder cancer. We demonstrate that LDHA is up-regulated in bladder cancer cells and promotes proliferation, invasion, and glycolysis. Additionally, we found that microRNA (miR)-200c directly targets LDHA in bladder cancer cells. Ectopic expression of miR-200c inhibited LDHA-induced glycolysis, cell proliferation, and invasion. Thus, targeting LDHA through miR-200c is a potential therapeutic strategy in bladder cancer.