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Picotamide, a dual TXB synthetase inhibitor and TXB receptor antagonist, reduces exercise-induced albuminuria in microalbuminuric patients with NIDDM
- Source :
- Diabetes. 42(1)
- Publication Year :
- 1993
-
Abstract
- We investigated the short-term effect of the TXB inhibitor picotamide on albuminuria induced by exercise in 15 microalbuminuric (i.e., with UAE at rest between 20 and 200 μg/min) type II diabetic patients (12 men and 3 women, age 56 ± 2, BMI 28 ± 1 kg/m2) and in six normal age-matched control subjects. The diabetic subjects performed five submaximal exercise tests (90% of theoretical heart rate) on a cycle ergometer: the first two under basal conditions; the third and fifth after subjects had received picotamide (900 mg/day) or placebo (3 tablets/day) for 10 days; the fourth exercise always was performed after 10 days of wash-out. Control subjects performed two exercises: the first in baseline conditions and the second after 10 days of picotamide administration (900 mg/day). When diabetic patients were untreated, a significant (P < 0.05) increase in UAE with respect to baseline levels was observed immediately after and 1 h after the exercise test. After picotamide administration, UAE significantly decreased (P < 0.05) immediately after and 1 h after exercise, as compared with diabetic patients given a placebo. In normal subjects, exercise was followed by a slight increase in UAE, which was not significantly affected by picotamide administration. Our results show that short-term administration of picotamide is associated with a reduction in UAE after exercise in type II diabetes patients with microalbuminuria while at rest. Picotamide, a TXB synthetase and receptor inhibitor, may decrease exercise-induced albuminuria in diabetic patients through a reduction in circulating TXB levels andinhibition of TXB action, which in turn may act by lowering glomerular capillary hydraulic pressure.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Endocrinology, Diabetes and Metabolism
Physical Exertion
Receptors, Thromboxane
Phthalic Acids
Renal function
Physical exercise
Blood Pressure
Placebo
Heart Rate
Reference Values
Internal medicine
Heart rate
Internal Medicine
Medicine
Picotamide
Albuminuria
Humans
Exercise
Glycated Hemoglobin
biology
business.industry
Middle Aged
medicine.disease
Endocrinology
Diabetes Mellitus, Type 2
biology.protein
Microalbuminuria
Female
Thromboxane-A synthase
Thromboxane-A Synthase
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 00121797
- Volume :
- 42
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi.dedup.....50820b0eb1324b974153d4ec69349aee