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Spa therapy induces clinical improvement and protein changes in patients with chronic back pain
- Source :
- Reumatismo, Vol 71, Iss 3 (2019)
- Publication Year :
- 2019
- Publisher :
- PAGEPress Publications, 2019.
-
Abstract
- This study is primarily aimed at assessing serum changes on a large panel of proteins in patients with chronic back pain following spa therapy, as well as evaluating different spa therapy regimens as a preliminary exploratory clinical study. Sixty-six patients with chronic back pain secondary to osteoarthritis were randomly enrolled and treated with daily mud packs and bicarbonate-alkaline mineral water baths, or a thermal hydrotherapy rehabilitation scheme, the combination of the two regimens or usual medication only (control group), for two weeks. Clinical variables were evaluated at baseline, after 2 and 12 weeks. One thousand serum proteins were tested before and after a two-week mud bath therapy. All spa treatment groups showed clinical benefit as determined by improvements in VAS pain, Roland Morris disability questionnaire and neck disability index at both time points. The following serum proteins were found greatly increased (≥2.5 fold) after spa treatment: inhibin beta A subunit (INHBA), activin A receptor type 2B (ACVR2B), angiopoietin-1 (ANGPT1), beta-2-microglobulin (B2M), growth differentiation factor 10 (GDF10), C-X-C motif chemokine ligand 5 (CXCL5), fibroblast growth factor 2 (FGF2), fibroblast growth factor 12 (FGF12), oxidized low density lipoprotein receptor 1 (OLR1), matrix metallopeptidase 13 (MMP13). Three proteins were found greatly decreased (≤0.65 fold): apolipoprotein C-III (Apoc3), interleukin 23 alpha subunit p19 (IL23A) and syndecan-1 (SDC1). Spa therapy was confirmed as beneficial for chronic back pain and proved to induce changes in proteins involved in functions such as gene expression modulation, differentiation, angiogenesis, tissue repair, acute and chronic inflammatory response.
- Subjects :
- Adult
Male
lcsh:Internal medicine
medicine.medical_specialty
medicine.medical_treatment
Matrix metallopeptidase 13
lcsh:Medicine
Osteoarthritis
mud therapy
Gastroenterology
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Rheumatology
Internal medicine
medicine
OLR1
Back pain
Humans
Single-Blind Method
030212 general & internal medicine
lcsh:RC31-1245
Hydrotherapy
Aged
G alpha subunit
030203 arthritis & rheumatology
business.industry
lcsh:R
Blood Proteins
Middle Aged
medicine.disease
Blood proteins
osteoarthritis
Treatment Outcome
balneology
rehabilitation
Chronic inflammatory response
Female
Chronic Pain
medicine.symptom
business
Subjects
Details
- ISSN :
- 22402683 and 00487449
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Reumatismo
- Accession number :
- edsair.doi.dedup.....506e983096a234e17b9a02f9d3a867a6