Back to Search
Start Over
Glucose metabolism in burn patients: the role of insulin and other endocrine hormones
- Source :
- Burns : journal of the International Society for Burn Injuries. 36(5)
- Publication Year :
- 2009
-
Abstract
- Severe burn causes a catabolic response with profound effects on glucose and muscle protein metabolism. This response is characterized by hyperglycemia and loss of muscle mass, both of which have been associated with significantly increased morbidity and mortality. In critically ill surgical patients, obtaining tight glycemic control with intensive insulin therapy was shown to reduce morbidity and mortality and has increasingly become the standard of care. In addition to its well-known anti-hyperglycemic action and reduction in infections, insulin promotes muscle anabolism and regulates the systemic inflammatory response. Despite a demonstrated benefit of insulin administration on the maintenance of skeletal muscle mass, it is unknown if this effect translates to improved clinical outcomes in the thermally injured. Further, insulin therapy has the potential to cause hypoglycemia and requires frequent monitoring of blood glucose levels. A better understanding of the clinical benefit associated with tight glycemic control in the burned patient, as well as newer strategies to achieve and maintain that control, may provide improved methods to reduce the clinical morbidity and mortality in the thermally injured patient.
- Subjects :
- Blood Glucose
medicine.medical_specialty
Anabolism
medicine.medical_treatment
Hypoglycemia
Carbohydrate metabolism
Critical Care and Intensive Care Medicine
Bioinformatics
law.invention
law
Internal medicine
medicine
Endocrine system
Humans
Hypoglycemic Agents
Insulin
Glycemic
business.industry
Gluconeogenesis
General Medicine
medicine.disease
Intensive care unit
Glucagon-like peptide-1
Metformin
Endocrinology
Hyperglycemia
Emergency Medicine
Surgery
Insulin Resistance
business
Burns
Subjects
Details
- ISSN :
- 18791409
- Volume :
- 36
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Burns : journal of the International Society for Burn Injuries
- Accession number :
- edsair.doi.dedup.....506a9ef8dd129d0ea9b8d04b5a05c0a6