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Grandmaternal high-fat diet primed anxiety-like behaviour in the second-generation female offspring
- Source :
- Winther, G, Eskelund, A, Richter, C B, Elfving, B, Müller, H K, Lund, S & Wegener, G 2019, ' Grandmaternal High-fat Diet Primed Anxiety-like Behaviour in the Second-Generation Female Offspring ', Behavioural Brain Research, vol. 359, pp. 47-55 . https://doi.org/10.1016/j.bbr.2018.10.017
- Publication Year :
- 2018
-
Abstract
- The health consequences of maternal obesity during pregnancy are disturbing as they may contribute to mental disorders in subsequent generations. We examine the influence of suboptimal grandmaternal diet on potential metabolic and mental health outcome of grand-progenies with a high-fat diet (HFD) manipulation in adulthood in a rat HFD model. Grandmaternal exposure to HFD exacerbated granddaughter's anxiety-like phenotype. Grandmaternal exposure to HFD led to upregulated corticotropin-releasing hormone receptor 2 mRNA expression involved in the stress axis in the male F2 offspring. Thus, we demonstrate that suboptimal grandmaternal diet prior to and during pregnancy and lactation may persist across subsequent generations. These findings have important implications for understanding both individual rates of metabolic and mental health problems and the clinical impact of current global trends towards comorbidity of obesity and depression and anxiety. In conclusion, the effect of grandmaternal HFD consumption during pregnancy on stress axis function and mental disorders may be transmitted to future generations.
- Subjects :
- Male
Offspring
Physiology
Anxiety
Diet, High-Fat
Hippocampus
Rats, Sprague-Dawley
03 medical and health sciences
Behavioral Neuroscience
Random Allocation
0302 clinical medicine
Pregnancy
Lactation
Medicine
Animals
Depression (differential diagnoses)
030304 developmental biology
0303 health sciences
Sex Characteristics
Behavior, Animal
business.industry
medicine.disease
Comorbidity
Mental health
Obesity
Disease Models, Animal
medicine.anatomical_structure
Prenatal Exposure Delayed Effects
Female
Disease Susceptibility
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18727549
- Volume :
- 359
- Database :
- OpenAIRE
- Journal :
- Behavioural brain research
- Accession number :
- edsair.doi.dedup.....50693f4df954f2300e0119293da1f24e