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Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites
- Source :
- Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. 33(1)
- Publication Year :
- 2003
-
Abstract
- Summary Aim Several injectable materials have been used as osteogenic bone substitutes. However, none has gained universal acceptance. This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation. Material and methods The composites were injected into the subcutaneous space on the dorsum of nude mice to investigate new bone tissue formation. The composites were examined histologically over a 12-week period. Results The composites injected into the mouse were able to stimulate new bone formation, which was trabecular in type. Conclusions This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone.
- Subjects :
- Bone Regeneration
Alginates
Mesenchyme
Bone Morphogenetic Protein 2
Mice, Nude
Bone morphogenetic protein
Bone tissue
Bone morphogenetic protein 2
Chitosan
chemistry.chemical_compound
Mice
Tissue engineering
Glucuronic Acid
Transforming Growth Factor beta
Medicine
Animals
Composite material
business.industry
Hexuronic Acids
Mesenchymal stem cell
Mesenchymal Stem Cells
medicine.anatomical_structure
Otorhinolaryngology
chemistry
Bone Morphogenetic Proteins
Bone Substitutes
Surgery
Oral Surgery
Stem cell
business
Gels
Subjects
Details
- ISSN :
- 10105182
- Volume :
- 33
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
- Accession number :
- edsair.doi.dedup.....5068fc6132d55a96d13c4b35abf24e1c