Breast cancer in a male with ankylosing spondylitis treated with TNFalpha antagonists

A 72-year-old male with a 4-year history of TNFα antagonist therapy (infliximab and etanercept) for ankylosing spondylitis was diagnosed with breast cancer. He had a family history of breast cancer. The low incidence and considerable severity of breast cancer in males, genetic risk factors, and potential role for TNFα antagonist therapy are discussed.