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Sex differences in proximal and distal nephron function contribute to the mechanism of idiopathic hypercalcuria in calcium stone formers
- Source :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 309:R85-R92
- Publication Year :
- 2015
- Publisher :
- American Physiological Society, 2015.
-
Abstract
- Idiopathic hypercalciuria (IH) is a common familial trait among patients with calcium nephrolithiasis. Previously, we have demonstrated that hypercalciuria is primarily due to reduced renal proximal and distal tubule calcium reabsorption. Here, using measurements of the clearances of sodium, calcium, and endogenous lithium taken from the General Clinical Research Center, we test the hypothesis that patterns of segmental nephron tubule calcium reabsorption differ between the sexes in IH and normal subjects. When the sexes are compared, we reconfirm the reduced proximal and distal calcium reabsorption. In IH women, distal nephron calcium reabsorption is decreased compared to normal women. In IH men, proximal tubule calcium reabsorption falls significantly, with a more modest reduction in distal calcium reabsorption compared to normal men. Additionally, we demonstrate that male IH patients have lower systolic blood pressures than normal males. We conclude that women and men differ in the way they produce the hypercalciuria of IH, with females reducing distal reabsorption and males primarily reducing proximal tubule function.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Fluid and Electrolyte Homeostasis
Lithium (medication)
Physiology
Hypercalciuria
chemistry.chemical_element
Blood Pressure
Nephron
Calcium
urologic and male genital diseases
Models, Biological
Kidney Tubules, Proximal
Kidney Calculi
Young Adult
Sex Factors
Physiology (medical)
Internal medicine
medicine
Humans
Magnesium
Kidney Tubules, Distal
Aged
business.industry
Reabsorption
Sodium
Renal Reabsorption
Fasting
Middle Aged
Postprandial Period
medicine.disease
medicine.anatomical_structure
Tubule
Endocrinology
Blood pressure
chemistry
Case-Control Studies
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 15221490 and 03636119
- Volume :
- 309
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Accession number :
- edsair.doi.dedup.....505fd987da544e26d85f58411bc15580