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Detrusor underactivity causes neurogenic voiding dysfunction in a rat bilateral accessory nerve-injury model
- Source :
- Journal of Pharmacological Sciences, Vol 146, Iss 2, Pp 116-119 (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- We aimed to investigate detrusor function in a previously developed rat neurogenic voiding dysfunction model that we have developed previously. We performed sham or bilateral accessory nerve injury (BACNI) surgeries on ten-week-old male Wistar/ST rats. One week after surgery, we evaluated detrusor contractility in the bladder using isometric tension and mRNA expression assays. Cholinergic contraction was attenuated in the injury model, whereas carbachol-evoked contraction was enhanced, and mRNA expression of the cholinergic receptor increased. These findings suggest that there was a reduction in neurotransmitter release causing detrusor underactivity.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Contraction (grammar)
Mrna expression
Accessory Nerve Injuries
Urinary Bladder
Urology
Gene Expression
Isometric exercise
RM1-950
urologic and male genital diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Isometric Contraction
Urinary Bladder, Underactive
Medicine
Animals
Receptors, Cholinergic
RNA, Messenger
Rats, Wistar
Urinary Bladder, Neurogenic
Neurotransmitter
Accessory nerve injury
Acetylcholine receptor
Pharmacology
Neurotransmitter Agents
business.industry
Detrusor contractility
Detrusor underactivity
female genital diseases and pregnancy complications
Voiding dysfunction
Disease Models, Animal
030104 developmental biology
chemistry
Molecular Medicine
Cholinergic
Rat
Carbachol
Therapeutics. Pharmacology
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 13478613
- Volume :
- 146
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacological Sciences
- Accession number :
- edsair.doi.dedup.....5059e1ce25ed67f5ac2b9a356758b649