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Korean First Prospective Phase II Study, Feasibility of Prone Position in Postoperative Whole Breast Radiotherapy: A Dosimetric Comparison
- Source :
- Cancer Research and Treatment : Official Journal of Korean Cancer Association
- Publication Year :
- 2019
- Publisher :
- Korean Cancer Association, 2019.
-
Abstract
- Purpose This first Korean prospective study is to evaluate the feasibility of prone breast radiotherapy after breast conserving surgery for left breast cancer patients who have relatively small breast size and we present dosimetric comparison between prone and supine positions. Materials and methods Fifty patients underwent two computed tomography (CT) simulations in supine and prone positions. Whole breast, ipsilateral lung, heart, and left-anterior-descending coronary artery were contoured on each simulation CT images. Tangential-fields treatment plan in each position was designed with total 50 Gy in 2-Gy fractions, and then one of the positions was designated for the treatment by comparing target coverage and dose to normal organs. Also, interfractional and intrafractional motion was evaluated using portal images. Results In total 50 patients, 32 cases were decided as prone-position-beneficial group and 18 cases as supine-position-beneficial group based on dosimetric advantage. Target dose homogeneity was comparable, but target conformity in prone position was closer to optimal than in supine position. For both group, prone position significantly increased lung volume. However, heart volumewas decreased by prone position for prone-position-beneficial group but was comparable between two positions for supine-position-beneficial group. Lung and heart doses were significantly decreased by prone position for prone-position-beneficial group. However, prone position for supine-position-beneficial group increased heart dose while decreasing lung dose. Prone position showed larger interfractional motion but smaller intra-fractional motion than supine position. Conclusion Prone breast radiotherapy could be beneficial to a subset of small breast patients since it substantially spared normal organs while achieving adequate target coverage.
- Subjects :
- Adult
Cancer Research
medicine.medical_specialty
Supine position
medicine.medical_treatment
Breast Neoplasms
Mastectomy, Segmental
Patient Positioning
Prone position
Republic of Korea
mental disorders
Breast-conserving surgery
medicine
Left-sided breast neoplasms
Humans
Computer Simulation
Lung volumes
Prospective Studies
Prospective cohort study
Lung
Radiotherapy
business.industry
Radiotherapy Planning, Computer-Assisted
Radiotherapy Dosage
Middle Aged
Clinical trial
Radiation therapy
medicine.anatomical_structure
Oncology
Feasibility Studies
Original Article
Female
Radiology
Tomography, X-Ray Computed
business
psychological phenomena and processes
Artery
Subjects
Details
- ISSN :
- 20059256 and 15982998
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Cancer Research and Treatment
- Accession number :
- edsair.doi.dedup.....504816db534555117a914eece1590929