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Hepatitis C status and infectious complications in the surgical intensive care unit: a retrospective analysis of 1,941 consecutive patients
- Source :
- The American Journal of Surgery. 211:1064-1070
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Background Hepatitis C virus (HCV) infection is thought to be associated with immune dysfunction. We hypothesized that HCV status would be associated with increased infectious complications in the surgical intensive care unit (SICU). Methods All patients admitted to our SICU between 2008 and 2012 were included. We evaluated 90-day mortality and infectious complications in the SICU. Multivariate logistic regression was performed to identify predictors of infectious complications and 90-day mortality. Results A total of 1,941 patients were included. The HCV-positive group had a higher overall incidence of infectious complications (25% vs 18%), particularly ventilator-associated pneumonia (VAP) and bacteremia. The increased incidences of VAP and bacteremia persisted when cirrhotic patients were excluded. Prolonged intubation (Odds Ratio [OR] = 2.1), abdominal surgery (OR = 1.6), and model for end-stage liver disease ≥ 15 (OR = 1.4) were independent predictors of SICU infectious complications. Conclusions The HCV-positive group had an increased incidence of infectious complications in the SICU, particularly VAP and bacteremia. This effect persisted when cirrhotic patients were excluded.
- Subjects :
- Adult
Male
medicine.medical_specialty
Critical Care
Databases, Factual
Bacteremia
Risk Assessment
Immunocompromised Host
03 medical and health sciences
Liver disease
Postoperative Complications
0302 clinical medicine
Cause of Death
Internal medicine
medicine
Humans
Hospital Mortality
030212 general & internal medicine
Survival rate
Aged
Retrospective Studies
Cross Infection
business.industry
Incidence (epidemiology)
030208 emergency & critical care medicine
Retrospective cohort study
General Medicine
Odds ratio
Hepatitis C
Hepatitis C, Chronic
Middle Aged
medicine.disease
United States
Surgery
Survival Rate
Intensive Care Units
Logistic Models
Multivariate Analysis
Female
business
Follow-Up Studies
Abdominal surgery
Subjects
Details
- ISSN :
- 00029610
- Volume :
- 211
- Database :
- OpenAIRE
- Journal :
- The American Journal of Surgery
- Accession number :
- edsair.doi.dedup.....5044af84cf7a4a1e6e4582371d0d0a33