Class II major histocompatibility complex molecule expression on murine eosinophils activated in vivo by Brugia malayi

The Th-2 response to microfilariae of Brugia malayi in BALB/c mice is associated with peritoneal eosinophilia. These eosinophils had an activated hypodense phenotype in vivo and expressed high levels of the class II major histocompatibility complex (MHC). Interleukin 4 up-regulated the class II MHC, whereas gamma interferon inhibited class II MHC expression on eosinophils.