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An Update on Cellular MicroRNA Expression in Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma
- Source :
- Oncology. 95(4)
- Publication Year :
- 2018
-
Abstract
- Squamous cell carcinoma of mucosal sites in the head and neck (HNSCC) is the sixth most common cause of cancer worldwide, and despite advances in conventional management, it still has significant morbidity and mortality associated with both diagnosis and treatment. Advances in our understanding of the biological mechanisms underlying this disease have demonstrated a significant difference between human papillomavirus (HPV)-associated, HPV and tobacco associated, and HPV-negative disease. It remains important to further elucidate the biologic and genetic differences between HPV-associated and tobacco-associated disease, with the aim of earlier diagnosis through screening, and advances in management including the development of novel therapeutic agents. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression, and have effects on almost every cellular function, and have potentially important applications to diagnosis, management and prognosis in HNSCC. Establishing a cellular miRNA expression profile for HPV-associated disease may therefore have important implications for the screening and treatment of this disease. This review summarises the current findings regarding miRNA expression in mucosal HNSCC, and focuses particularly on miRNA expression in HPV-associated tumours.
- Subjects :
- 0301 basic medicine
Cancer Research
Disease
03 medical and health sciences
0302 clinical medicine
microRNA
Gene expression
medicine
Animals
Humans
Papillomaviridae
Human papillomavirus
biology
business.industry
Squamous Cell Carcinoma of Head and Neck
Significant difference
Papillomavirus Infections
Cancer
General Medicine
medicine.disease
biology.organism_classification
Head and neck squamous-cell carcinoma
MicroRNAs
030104 developmental biology
Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Cancer research
Carcinoma, Squamous Cell
business
Subjects
Details
- ISSN :
- 14230232
- Volume :
- 95
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Oncology
- Accession number :
- edsair.doi.dedup.....5033f812ef851ab7c15d7d404a70f19b