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Histopathologic and Ultrastructural Features and Claudin Expression in Papillary Tumors of the Pineal Region
- Source :
- American Journal of Surgical Pathology, American Journal of Surgical Pathology, Lippincott, Williams & Wilkins, 2012, 36 (6), pp.916-928. ⟨10.1097/PAS.0b013e31824b7114⟩, The American Journal of Surgical Pathology, American Journal of Surgical Pathology, 2012, 36 (6), pp.916-928. ⟨10.1097/PAS.0b013e31824b7114⟩
- Publication Year :
- 2012
- Publisher :
- HAL CCSD, 2012.
-
Abstract
- Neuroepithelial papillary tumor of the pineal region (PTPR) has been defined as a distinct entity that is increasingly being recognized, with 96 cases now reported. This tumor shares morphologic features with both ependymomas and choroid plexus tumors. PTPR is characterized by an epithelial-like growth pattern in which the vessels are covered by layers of tumor cells forming perivascular pseudorosettes. These tumors exhibit various combinations of papillary and solid architecture, making the differential diagnosis of PTPR difficult to establish. We report the detailed description of the histopathologic features of a large series of PTPRs from 20 different centers and distinguish 2 subgroups of tumors with either a striking papillary growth pattern or a papillary and solid growth pattern. We highlight the findings that PTPRs have unusual vessels with multiple lumina and frequently show detachment of the border of the tumoral cells from the vascular wall. The 2 PTPR subgroups present similar clinical characteristics and immunophenotypes. We confirmed and extended the results of previous ultrastructural studies on the presence of intercellular junctions at the apical part of tumoral cells. The expression of the tight junction proteins claudin-1, claudin-2, and claudin-3 was investigated by immunohistochemistry. Claudin-1 and claudin-3, but not claudin-2, were expressed in PTPRs and in the fetal subcommissural organ, potentially the origin of this tumor. In contrast, all 3 claudins were expressed in choroid plexus papillomas. Claudin expression may help in the diagnosis of PTPRs and can be used in combination with other markers, such as CK18, NCAM, E-cadherin, MAP-2, and Kir 7.1.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Adolescent
[SDV]Life Sciences [q-bio]
Biology
Pathology and Forensic Medicine
Tight Junctions
03 medical and health sciences
Young Adult
0302 clinical medicine
medicine
Biomarkers, Tumor
Humans
Papillary tumors of the pineal region
Claudin
PTPRS
Child
ComputingMilieux_MISCELLANEOUS
Aged
Ultrasonography
Papillary tumor
Middle Aged
medicine.disease
Carcinoma, Papillary
Neuroepithelial cell
030220 oncology & carcinogenesis
Child, Preschool
Claudins
Pinealoma
Surgery
Choroid plexus
Female
Anatomy
030217 neurology & neurosurgery
Subcommissural organ
Subjects
Details
- Language :
- English
- ISSN :
- 01475185
- Database :
- OpenAIRE
- Journal :
- American Journal of Surgical Pathology, American Journal of Surgical Pathology, Lippincott, Williams & Wilkins, 2012, 36 (6), pp.916-928. ⟨10.1097/PAS.0b013e31824b7114⟩, The American Journal of Surgical Pathology, American Journal of Surgical Pathology, 2012, 36 (6), pp.916-928. ⟨10.1097/PAS.0b013e31824b7114⟩
- Accession number :
- edsair.doi.dedup.....5030209398fa534bbc702f2d169bef43