Back to Search
Start Over
Lower dopamine transporter binding potential in striatum during depression
- Source :
- Neuroreport. 12:4121-4125
- Publication Year :
- 2001
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2001.
-
Abstract
- Previous studies suggest that there is a dopamine lowering process during major depressive episodes (MDE). To investigate this, we measured the dopamine transporter binding potential (DAT BP) in the striatum of depressed and healthy subjects using [(11)C]RTI-32 PET. The DAT, a predominantly presynaptic receptor, decreases in density after chronic dopamine depletion and the BP is proportional to receptor density. In all striatal regions, subjects with MDE had significantly lower DAT BP. Low striatal DAT BP in MDE is consistent with a downregulation of DAT in response to a dopamine lowering process. There was also a strong, highly significant, inverse correlation between striatal DAT BP and neuropsychological tests of dopamine-implicated symptoms in patients (i.e. patients with lower DAT BP performed better). Lower DAT BP itself reduces extracellular clearance of dopamine. Patients who did not decrease their striatal DAT BP failed to compensate for low dopamine and showed greater impairment on dopamine related tests.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Dopamine Plasma Membrane Transport Proteins
Nerve Tissue Proteins
Striatum
Neuropsychological Tests
chemistry.chemical_compound
Cocaine
Dopamine
Internal medicine
parasitic diseases
mental disorders
Basal ganglia
medicine
Humans
Carbon Radioisotopes
Neurotransmitter
Dopamine transporter
Depressive Disorder, Major
Membrane Glycoproteins
biology
business.industry
General Neuroscience
Membrane Transport Proteins
food and beverages
Binding potential
Middle Aged
Corpus Striatum
Endocrinology
nervous system
chemistry
biology.protein
Catecholamine
Female
business
Tomography, Emission-Computed
medicine.drug
Subjects
Details
- ISSN :
- 09594965
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Neuroreport
- Accession number :
- edsair.doi.dedup.....5027bb1d175a7e02ced19bf595fd9f52