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Topical advances in wound care
- Source :
- Gynecologic Oncology. 111:S70-S80
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- There are fundamental differences between acute wounds that proceed to uncomplicated healing and those that become chronic wounds. Non-healing or chronic wounds can result from a combination of overlapping factors that prevent healing, including local tissue ischemia, repetitive trauma and ischemia/reperfusion injury, presence of tissue necrosis, impaired cellular and systemic host response to stress, and critical bacterial contamination. The bacterial burden in the wound contributes to a sustained inflammatory state, which inhibits normal progression to the proliferative phase of healing, thereby preventing restoration of tissue integrity. Appropriate wound bed preparation removes local barriers to healing and optimizes the tissue environment to achieve wound healing. It is an essential element of wound management that advances endogenous healing as well as the efficacy of topical and other wound therapy. This article will summarize a systematic approach to wound bed preparation using the "TIME" principle, and will highlight important advances in topical wound care.
- Subjects :
- Chronic wound
Wound Healing
medicine.medical_specialty
Wound therapy
integumentary system
business.industry
Ischemia
Obstetrics and Gynecology
medicine.disease
Bandages
Wound care
Oncology
Wound bed preparation
Anesthesia
Chronic Disease
Wound Infection
medicine
Humans
Wounds and Injuries
Tissue necrosis
medicine.symptom
Intensive care medicine
Wound healing
business
Reperfusion injury
Subjects
Details
- ISSN :
- 00908258
- Volume :
- 111
- Database :
- OpenAIRE
- Journal :
- Gynecologic Oncology
- Accession number :
- edsair.doi.dedup.....501f57eb7728d8f6a708074b386d230e