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Impact of Insulin Treatment on Prognosis of non-B non-C Hepatocellular Carcinoma After Hepatectomy
- Source :
- Anticancer Research. 41:317-326
- Publication Year :
- 2021
- Publisher :
- Anticancer Research USA Inc., 2021.
-
Abstract
- Background/aim Several studies have reported that DM is closely associated with an increased incidence of hepatocellular carcinoma (HCC). To clarify the effects of diabetes mellitus (DM) and antidiabetic medications on the prognosis of patients with non-B non-C (NBNC) HCC following curative initial hepatectomy. Patients and methods HCC patients (n=156) were divided into three groups according to the presence or absence of chronic viral hepatitis: hepatitis B virus (HBV) group, hepatitis C virus (HCV) group, and NBNC group. The clinical characteristics and survival outcomes were compared. In the NBNC group, univariate and multivariate analyses were conducted to determine prognostic factors. Results The NBNC group had a higher incidence of DM, ethanol intake, and large nodules than the other groups. Disease-free survival (DFS) was significantly worse in the NBNC group than in the HBV group. In the NBNC group, insulin treatment was an independent prognostic factor for DFS and overall survival (OS). Conclusion Medications for DM that affect insulin resistance might be appropriate prognostic factors for NBNC-HCC.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Carcinoma, Hepatocellular
Survival
medicine.medical_treatment
Hepatitis C virus
Insulins
medicine.disease_cause
Gastroenterology
Insulin resistance
Diabetes mellitus
Internal medicine
Diabetes Mellitus
medicine
Hepatectomy
Humans
Aged
Postoperative Care
Hepatitis B virus
business.industry
Insulin
Liver Neoplasms
General Medicine
Middle Aged
Prognosis
medicine.disease
digestive system diseases
Oncology
Hepatocellular carcinoma
Female
Disease Susceptibility
business
Viral hepatitis
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....5017b7d60c279849b0b25c93e81f0bfa