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Gas6 as a putative noninvasive biomarker of hepatic fibrosis
- Source :
- Biomarkers in medicine. 10(12)
- Publication Year :
- 2016
-
Abstract
- Aim: To evaluate serum growth arrest-specific gene 6 (Gas6) concentration as a biomarker of liver fibrosis progression. Materials & methods: One hundred and thirteen consecutive patients affected by chronic liver disease underwent transient elastography, Gas6 measurement and, if clinically indicated, liver biopsy. Results: Gas6 concentration was directly correlated to liver stiffness (r = 0.67; p < 0.0001) and was significantly higher in patients with advanced fibrosis (Ishak 4–5; p < 0.001). A plasma concentration 42 ng/ml identified severe fibrosis with a sensitivity of 64% and a specificity of 95%; the diagnostic accuracy was comparable to that of transient elastography. Conclusion: Gas6 is a novel biomarker of liver fibrosis, with a potential clinical and pathophysiological relevance.
- Subjects :
- Liver Cirrhosis
Male
Pathology
medicine.medical_specialty
Cirrhosis
Clinical Biochemistry
Chronic liver disease
Sensitivity and Specificity
03 medical and health sciences
0302 clinical medicine
Fibrosis
Drug Discovery
Medicine
Humans
Aged
medicine.diagnostic_test
business.industry
Biochemistry (medical)
Hepatitis C
Middle Aged
medicine.disease
Hepatitis B
Liver
ROC Curve
030220 oncology & carcinogenesis
Liver biopsy
Area Under Curve
Biomarker (medicine)
Elasticity Imaging Techniques
Intercellular Signaling Peptides and Proteins
030211 gastroenterology & hepatology
Female
business
Transient elastography
Hepatic fibrosis
Biomarkers
Subjects
Details
- ISSN :
- 17520371
- Volume :
- 10
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Biomarkers in medicine
- Accession number :
- edsair.doi.dedup.....5004017bd2574d31d16b4bb50c7c0d3d