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Microbial colonization and lung function in adolescents with cystic fibrosis
- Source :
- Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 15(3)
- Publication Year :
- 2015
-
Abstract
- With intensified antibiotic therapy and longer survival, patients with cystic fibrosis (CF) are colonized with a more complex pattern of bacteria and fungi. However, the clinical relevance of these emerging pathogens for lung function remains poorly defined. The aim of this study was to assess the association of bacterial and fungal colonization patterns with lung function in adolescent patients with CF. Microbial colonization patterns and lung function parameters were assessed in 770 adolescent European (German/Austrian) CF patients in a retrospective study (median follow-up time: 10years). Colonization with Pseudomonas aeruginosa and MRSA were most strongly associated with loss of lung function, while mainly colonization with Haemophilus influenzae was associated with preserved lung function. Aspergillus fumigatus was the only species that was associated with an increased risk for infection with P. aeruginosa. Microbial interaction analysis revealed three distinct microbial clusters within the longitudinal course of CF lung disease. Collectively, this study identified potentially protective and harmful microbial colonization patterns in adolescent CF patients. Further studies in different patient cohorts are required to evaluate these microbial patterns and to assess their clinical relevance.
- Subjects :
- Pulmonary and Respiratory Medicine
Male
Methicillin-Resistant Staphylococcus aureus
Adolescent
Cystic Fibrosis
Statistics as Topic
medicine.disease_cause
Staphylococcal infections
Cystic fibrosis
Haemophilus influenzae
Microbiology
03 medical and health sciences
0302 clinical medicine
Germany
medicine
Humans
Clinical significance
Colonization
Pseudomonas Infections
030212 general & internal medicine
Lung
Pseudomonas aeruginosa
business.industry
Aspergillus fumigatus
Staphylococcal Infections
medicine.disease
Methicillin-resistant Staphylococcus aureus
Respiratory Function Tests
medicine.anatomical_structure
030228 respiratory system
Austria
Pediatrics, Perinatology and Child Health
Immunology
Microbial Interactions
Female
Pulmonary Aspergillosis
business
Subjects
Details
- ISSN :
- 18735010
- Volume :
- 15
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
- Accession number :
- edsair.doi.dedup.....4ffd516001c22b05bb01fbd9576e5faf