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Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia: Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury
- Source :
- HPB Surgery, Vol 2013 (2013), HPB Surgery
- Publication Year :
- 2013
- Publisher :
- Hindawi Limited, 2013.
-
Abstract
- Pentoxifylline (PTX) has been shown to have beneficial effects on microcirculatory blood flow. In this study we evaluate the potential hemodynamic and metabolic benefits of PTX during hepatic ischemia. We also test the hypothesis that portal PTX infusion can minimize the I/R injury when compared to systemic infusion. Methods. Twenty-four dogs ( kg) were subjected to portal triad occlusion (PTO) for 45 min. The animals were assigned to 3 groups: CT (control, PTO, ), PTX-syst (PTO + 25 mg/Kg of PTX IV, ), and PTX-pv (PTO + 25 mg/Kg of PTX in the portal vein, ). Animals were followed for 120 min. Systemic hemodynamics, gastrointestinal tract perfusion, oxygen-derived variables, and liver enzymes were evaluated throughout the experiment. Results. Animals treated with PTX presented significantly higher CO in the first hour after reperfusion, when compared to the CT (~3.7 vs. 2.1 L/min, ). Alanine aminotransferase (ALT) was similar in the PTX groups two hours after reperfusion but significantly higher in the CT (227 vs. ~64 U/L, ). Conclusion. PTX infusion was associated with hemodynamic benefits and was able to minimize liver injury during normothermic hepatic I/R. However, local PTX infusion was not associated with any significant advantage over systemic route.
- Subjects :
- endocrine system
medicine.medical_specialty
Portal triad
Article Subject
lcsh:Surgery
Hemodynamics
complex mixtures
Pentoxifylline
Occlusion
Medicine
lcsh:RC799-869
Hepatology
business.industry
lcsh:RD1-811
Blood flow
medicine.disease
Liver ischemia
Surgery
Hepatic ischemia
medicine.anatomical_structure
Anesthesia
lcsh:Diseases of the digestive system. Gastroenterology
business
Reperfusion injury
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 16078462 and 08948569
- Volume :
- 2013
- Database :
- OpenAIRE
- Journal :
- HPB Surgery
- Accession number :
- edsair.doi.dedup.....4ff868427854117fa5ea918722b714a3