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Antiplasmodial Activity of Stigmastane Steroids from Dryobalanops oblongifolia Stem Bark
- Source :
- Open Chemistry, Vol 18, Iss 1, Pp 259-264 (2020)
- Publication Year :
- 2020
- Publisher :
- De Gruyter, 2020.
-
Abstract
- Three stigmastane steroids: 6-hydroxystigmast-4-en-3-one (1), stigmast-4-en-3-one (2), and 3-hydroxystigmast-5-en-7-one (3) were successfully isolated from the acetone extract of Dryobalanps oblongifolia stem bark. The structural determination of isolated compounds was carried out on the basis of data analysis of NMR and MS spectra. In order to identify the antiplasmodial activity, the isolated compound was put to test against Plasmodium falciparum 3D7. Antiplasmodial activity of the isolated compounds showed that the IC50 values of 6-hydroxystigmast-4-en-3-one were 37.29 μg/mL while the IC50 values of stigmast-4-en-3-one were 43.54 μg/mL and the IC50 values of 3-hydroxystigmast-5-en-7-one were 13.34 μg/mL (chloroquine phosphate was used as a positive control, IC50 0.006 μg/mL). Judging from the results, the isolated compounds were proven to demonstrate mediocre antiplasmodial activity. Compound (3) indicated a better antimalarial activity than compound (1) and (2), even though there was no satisfactory activity that indicated its ability to combat chloroquine. Therefore, it might not be developed as an antimalarial drug.
- Subjects :
- plasmodium falciparum
010402 general chemistry
01 natural sciences
chemistry.chemical_compound
Chloroquine
antiplasmodial
Materials Chemistry
Acetone
medicine
Ic50 values
IC50
dryobalanops oblongifolia
QD1-999
Stem bark
biology
Traditional medicine
stigmastane steroid
Plasmodium falciparum
General Chemistry
biology.organism_classification
Chloroquine Phosphate
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Chemistry
chemistry
Dryobalanops oblongifolia
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 23915420
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Open Chemistry
- Accession number :
- edsair.doi.dedup.....4fd7079778932787f4d9fb77a6124528