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The effect of antiretroviral treatment of different durations in primary HIV infection
- Source :
- AIDS (London, England), 22(18), 2441-2450. Lippincott Williams and Wilkins
- Publication Year :
- 2008
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2008.
-
Abstract
- OBJECTIVES: To compare immunological, virological and clinical outcomes in persons initiating combination antiretroviral therapy (cART of different durations within 6 months of seroconversion (early treated) with those who deferred therapy (deferred group). DESIGN: CD4 cell and HIV-RNA measurements for 'early treated' individuals following treatment cessation were compared with the corresponding ART-free period for the 'deferred' group using piecewise linear mixed models. Individuals identified during primary HIV infection were included if they seroconverted from 1st January 1996 and were at least 15 years of age at seroconversion. Those with at least 2 CD4 less than 350 cells/microl or AIDS within the first 6 months following seroconversion were excluded. RESULTS: Of 348 'early treated' patients, 147 stopped cART following treatment for at least 6 (n = 38), more than 6-12 (n = 40) or more than 12 months (n = 69). CD4 cell loss was steeper for the first 6 months following cART cessation, but subsequent loss rate was similar to the 'deferred' group (n = 675, P = 0.26). Although those treated for more than 12 months appeared to maintain higher CD4 cell counts following cART cessation, those treated for 12 months or less had CD4 cell counts 6 months after cessation comparable to those in the 'deferred' group. There was no difference in HIV-RNA set points between the 'early' and 'deferred' groups (P = 0.57). AIDS rates were similar but death rates, mainly due to non-AIDS causes, were higher in the 'deferred' group (P = 0.05). CONCLUSION: Transient cART, initiated within 6 months of seroconversion, seems to have no effect on viral load set point and limited beneficial effect on CD4 cell levels in individuals treated for more than 12 months. Its long-term effects remain inconclusive and need further investigation
- Subjects :
- Adult
Male
Cart
Pediatrics
medicine.medical_specialty
Adolescent
Immunology
HIV Infections
Drug Administration Schedule
Young Adult
Acquired immunodeficiency syndrome (AIDS)
medicine
Humans
Immunology and Allergy
Young adult
Seroconversion
Sida
biology
business.industry
Age Factors
Viral Load
medicine.disease
biology.organism_classification
CD4 Lymphocyte Count
Surgery
Treatment Outcome
Infectious Diseases
Anti-Retroviral Agents
Cohort
Disease Progression
HIV-1
RNA, Viral
Drug Therapy, Combination
Female
Viral disease
business
Viral load
Subjects
Details
- ISSN :
- 02699370
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- AIDS
- Accession number :
- edsair.doi.dedup.....4fd360320e9191991e497414415042d2